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NameHsin-Fu Chen
Office phone number2312-3456 ext.71507
Office5F., No.2, Xuzhou Rd., Zhongzheng Dist., Taipei City 100, Taiwan
E-mail
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CategoryFull-Time
Job titleProfessor
Research expertisereproductive endocrinology, biology of pluripotent stem cells, infertility obstetrics and gynecology
Research DescriptionIn the past years, Dr. Chen continues the past research interests, focusing primarily on topics related to infertility treatment, human reproductive endocrinology, such as polycystic ovary syndrome (PCOS), embryonic development and human pluripotent stem cells, including human embryonic stem (ES) cells and induced pluripotent stem (iPS) cells.
Firstly in 2004, under the supervision by Prof. Ho (Hong-Nerng Ho), Dr. Chen’s lab has derived 3 human ES cell lines of Taiwanese ancestry. These 3 cell lines had been well characterized about the morphology, growth speed, karyotypes, in vivo and in vitro differentiation potential, gene expression profiles and telomerase activity etc. Specifically these cells were proved to be capable of differentiating into germ cell lineage, including the development into ovarian follicle-like structures and the expression of germ cell markers, including VASA and SCP3 etc. This paper was published in Feb issue of Human Reproduction 2007 and the Figures in the paper was selected as the cover figures of this specific issue (please refer to figure). These studies confirmed that these human ES cell lines will be most useful cell for future pluripotent stem cell study. Dr. Chen’s lab is continuously working hard on this topic, and hopefully a useful experimental model, development from stem cells to germ cells, can be established for subsequent study on testing chemicals to improve human germ cell development and survival. Now further study on stem cell to germ differentiation by using a transgenic Oct4-eGFP H9 human ES cell line has been completed and the paper will be submitted within 2 weeks. Read More...

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