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NamePo-Han Lin
Office phone number2312-3456 ext 71928
E-mail
CategoryClinical
Job titleAssistant Professor
Research expertisecancer genetics/genomics, breast cancer, cancer biology
Research DescriptionThe research interests of our team are (1) cancer genetics, especially hereditary breast cancer syndrome (2) breast cancer, focusing on mechanism of cancer recurrence, and (3) genetic diagnosis by next-generation sequencing (NGS).
(1) Cancer genetics
Since 2014, we started to explore the genetic impact of breast cancer development. The preliminary result showed about 23% of patients with early-onset or a familial history of breast cancer carrying germline deleterious mutations, 10 in BRCA1, 12 in BRCA2, 2 in RAD50, 2 in RAD51C, 2 in TP53 and one each in ATM, BRIP1, FANCI, MSH2, and MUTYH (Oncotarget. 2016;7(7):8310-20). In the future, we keep enroll candidate patients and try to investigate the cancer penetrance, genetic modifiers, and impacts of gene-environmental interaction in the mutation carriers. We also prescribe the genetic counseling to mutation carriers and advise them targeted organs screening for prevention of advanced malignancy.
(2) Breast cancer, focusing on mechanism of cancer recurrence
We started to investigate the molecular mechanism of breast cancer recurrence by using NGS technology.
(3) Genetic diagnosis by NGS
Precision oncology is an approach to patient care that allows doctors to select treatments based on a genetic understanding of their disease. Therefore, to establish a robust molecular diagnosis is the first step to achieve this goal. In the past two years, we had completed the target gene sequencing in acute myeloid leukemia (Cancer Med. 2017;6(2):349-360) and pancreatic neuroendocrine tumor (Int J Biol Sci. 2016;12(12):1523-1532.). Now, we are interesting in the technology of target gene enrichment (method of library preparation) and post-NGS bioinformatics. We would like to improve these field and use them in cancer gene diagnosis.
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