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NameYi-Cheng Chang
Office phone number2312-3456 ext.88656
Office5F., No.2, Xuzhou Rd., Zhongzheng Dist., Taipei City 100, Taiwan
E-mail
Reference website of individual researchPlease click herePlease click here
CategoryFull-Time
Job titleAssistant Professor
Research expertiseHuman and mouse genetic study for diabetes, obesity, and hypertension
Research DescriptionThe main research focus of our team is (1) human and mouse genetic studies for type 2 diabetes, obesity, and related metabolic traits (2) translational research of type 2 diabetes and obesity. We aimed to identify genetic loci for type 2 diabetes, obesity, and related metabolic traits in human. We further validated these findings in genetically modified mice model and dissected molecular mechanisms underlying the associations. We are currently trying to develop small-molecules for treatment for type 2 diabetes and obesity. We hope these efforts can be translated to clinical therapy for patients with type 2 diabetes and obesity.

Our current research projects include:
1.Genome-wide linkage or association approaches to identify genetic loci for type 2 diabetes, obesity, and related metabolic traits in human using case-control or family design.
2.Generation of transgenic mice to validate our findings from human genetics and to dissect molecular mechanisms. Based on the identified mechanism, we thought to screen small molecules for treatment.
3.Current, we identify possible targets to treat type 2 diabetes and obesity including enzymes involved in aldehydes and prostaglandins metabolism as well as redox control.
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