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[演講] 9/11:郭保麟教授主講:Septin12 and sperm differentiation

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張貼人:網站管理員公告日期:2017-08-16
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臺大基蛋所Medical Genetics & Genomics Monthly Seminar演講邀請

[講題]Septin12 and sperm differentiation

[講者]郭保麟 教授 (成大醫學院婦產科教授,CV詳如附件)

[時間]9/11 (星期一) 上午 1120-1210

[地點]醫學院基醫大樓 202講堂

[演講摘要]

Septins are a family of cytoskeletal proteins with GTPase activity. Different septins usually assembly to form complexs and further polymerize into filaments and rings. They are assembled as intracellular filaments scaffolds, involved in cytokinesis, cellular morphogenesis, neural polarity, vesicle trafficking and spermatogenesis. .

 

During the past 10 years, I carried out a series of experiments to explore how SEPT12 is involved in regulating sperm differentiation. The findings of my previous studies are summarized as follows

(1)    The infertile patients carrying SEPT12 mutations presented with deformed and immotile sperm.

(2)    The sperm of the SEPT12 KO mouse showed severe defects of all four compartments: acrosome, nucleus, midpiece and tail.

(3)    SEPT12 forms filaments consisting of SEPT12-7-6-2-2-6-7-12 (or SEPT12-7-6-4-4-6-7-12) complexes in the sperm annulus.

(4)    Protein kinase A (PKA) is responsible for SEPT12 phosphorylation at Ser198 residue and this modification is important for SEPT12 sperm annulus establishment and male fertility.

(5)    SEPT12 phosphorylation/dephosphorylation is involved in migration of sperm annulus along sperm tail. Sperm annulus, a septin-organized fibrous structure, is originally organized at sperm neck and then moves downward the sperm tail.

 

Infertility is a rising issue in the world. WHO has calculated that over 10% of couple is with infertility. Male contraception is also an emerging market given contraception is of equal responsibility for man and woman. Because SEPT12 protein is exclusively expressed in the mature sperm and is critical for sperm differentiation, it will be an ideal target for the development of male contraceptive.

 

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臺大基蛋所 陳信孚所長 臺大醫院基因醫學部 高淑芬主任 敬邀

最後修改時間:2017-08-16 PM 2:46

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