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[演講] 3/13:蔡幸真老師主講:Cancer epigenetics – linking basic biology to clinical medicine

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張貼人:網站管理員公告日期:2017-03-01
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 臺大基蛋所Medical Genetics & Genomics Monthly Seminar邀請
 
[講題]:Cancer epigenetics – linking basic biology to clinical medicine
[講者]:蔡幸真 助理教授 (CV詳如附件)
[時間]:3/13 (星期一) 上午 11:20-12:10
[地點]:醫學院基醫大樓 202講堂
[演講摘要]

Dysregulation of epigenetic control events such as abnormal DNA methylation are critical contributors to the pathogenesis of cancer. A better understanding of these epigenetic abnormalities has significant therapeutic and diagnostic implications. Therapeutically, reversal of DNA methylation marks has become attractive strategies in cancer management as methylation-mediated silencing of tumor suppressor genes is a common event in many types of cancer. Despite the well-known biochemical reaction of DNA demethylating agents in cancer cells, their key molecular and cellular effects leading to clinical responses remained elusive. We deciphered the complex mechanisms of action of these drugs behind their clinical efficacy in hematological malignancies, and explored their potential uses in epithelial cancers, particularly as sensitization agents to other therapeutic measures including cancer immunotherapy. In addition, we revisited the roles of major DNA methyltransferases (DNMTs) in sustaining cancer-specific DNA methylation through a series of titrated knockdown studies and CRISPR technology with a focus towards refining DNA demethylating therapy. Diagnostically, DNA methylation is an early event during carcinogenesis. Methylated DNA may shed into the circulation of cancer patients. We identified promising cancer-specific methylation loci via bioinformatic and experimental approaches, which paves the way to developing blood-based diagnostic assays for patients with non-small cell lung cancer.

 
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